This presentation will discuss a unique and practical learning framework – VirtECS (Virtually Exhaustive Combinatorial System) – to rapidly (1) enable a high-fidelity model of bioprocessing and (2) search the many possible process schedules to find a high-performance way to operate. VirtECS improves capital efficiency, drives throughput increases, and promotes cost reduction. VirtECS can be used to establish manufacturing social media that promotes continuous improvement, complexity mitigation, and teamwork.